Aim
To provide insight into the background for and the development of somatic gene therapy as treatment alternative for a number of diseases with basis in hematology and retrovirology.
Contents
The basis of the course is cellular and molecular aspects of normal and malignant hematopoiesis focusing on diseases involving blood and bone marrow. Employed and theoretical gene therapy strategies will be presented. We will discuss design of vectors for introduction of new genetic material into human primary cells, packaging cell lines for vector production, and design of gene therapy protocols.
The course will deal with both molecular and medical problems in relation to gene therapy as treatment.
Form and duration: Three adjoining lessons a week for 9 weeks consisting of one hour with presentation of the subject of the following week and two hours group discussion.
Compulsary programme: The entire course.
Qualification: Completion of three years of study in biology or molecular biology.
Text-books
Original literature (will be handed out at the course).
Evaluation
Passing is based upon at least 80% registered attendance and participation in group discussions.
ECTS-credits
5
Semester
Fall