OrCh 406 Pharmaceutical and Combinatorial Chemistry
Contents The course gives and introduction to the biorganic chemical knowledge and the techniques required for designing, producing and/or finding bioactive substances. The following subjects will be discussed: Intermolecular interactions, bioisosteric groups, qualitative and quantitative structure-activity relations, modelling, solid-phase synthesis, combinatorial chemical methods including parallel synthesis and split and mix. Laboratory exercises in solid-phase synthesis and combinatorial chemistry are included in the course.
Text-books F.D. King: Medicinal Chemistry. Principles and Practice.
Evaluation Pass/fail judged from active participation and written essays
ECTS credits 10
Semester Spring