Homepage of the course
http://daimi.au.dk/~schauser/genome_analysis_E03/
Credits
5 ECTS
Aim
Sequencing and identifying genes in complex genomes is a difficult task. The course focuses on how the computer can solve this problem, and which helper data can be used. Furthermore, the course will deal with the global analysis of gene regulation and metabolic networks.
Contents
1. Gene finding: What biological signals can be used in the development of statistical models for gene structure prediction and how can the results be evaluated?
2. Microarray data analysis: datamining tools, clustering, reconstruction of regulatory pathways, inference of function of unknown genes
3. Genome projects: whole genome assembly, comparison of genomes, searches for regulatory sequences, reconstruction of metabolic pathways.
4. Experimental bioinformatics: protein interaction networks, Expressed Sequence Tags (EST) analysis
Term
2nd quarter
Prerequisites
Passed Introduction to bioinformatics
Type of classes
14 lectures
14 seminars
21 computer exercises
Type of evaluation and aids
Project-thesis evaluated according to the 13-point scale with intern examiner
Educational materials
Textbook: Bioinformatics – Sequence and Genome Analysis
Author: D. W. Mount
Publishing house: Cold Spring Harbor Laboratory Press
ISBN No: 0-87969-608-7
Supplementary material
Original articles
Responsible teacher
Name: Leif Schauser
Office address: Bd 90. 121
Phone no: 8942 3239
E-mail: schauser@daimi.au.dk
Other teachers
Asger Hobolth
Max participants
No limit
Language
Material: English
Spoken language: Danish/English