Neuroscience
In the Neuroscience Theme, we have over 25 specialized research groups dedicated to unravelling the mysteries behind neural functions.
Our focus spans from understanding molecular changes impacting cell signalling in the Central Nervous System (CNS) to regulating crucial aspects such as memory, stress responses, neurodegenerative diseases, and the effects of drugs.
We use cutting-edge technologies in molecular and cellular biology, circuit neuroscience, neuroimaging, and neuropharmacology. Our methods include sophisticated in vitro and in vivo models, allowing us to probe deeper into the complexities of the brain.
Join our vibrant and collaborative community, where researchers and students from diverse backgrounds and nationalities come together. Here, you'll have the opportunity to work closely with clinicians and pharmaceutical companies, fostering an environment for groundbreaking and translational discoveries.
Characterization of emotional brain circuits
Description
Emotion affects our cognitive functions and social behavior. However, we do not know how emotion is represented in our brain yet. My group studies emotional brain circuits and its contributions to psychiatric diseases using mouse models. In this project, students will be able to learn basic and advanced circuit analysis methods, including neuro-tracing tools, fluorescent image analysis, and immunohistochemistry.
Keywords
Brain circuit, Anatomy, Emotion, Psychiatric disease
Decoding cell states and fates
Description
How do cells navigate their developmental pathways to assume specific fates, and how does their behaviour adapt under a range of physiological and pathological conditions?
We explore the mechanisms of cell fate determination and the dynamic states cells adopt in response to varying environments, which are crucial for understanding the intricacies of normal development and disease pathogenesis
Keywords
Neurodegeneration, Neurodevelopment
Relevance of neuronal trafficking receptors for human brain development and disease
Short description
Investigating (a) the roles of sorting receptors SORCS1 and SORCS2 in the development and adult brain and (b) the effects of endocannabinoids in Alzheimer´s disease. Unravelling new concepts defining neuronal integrity and activity.
Keywords
Neuroscience, Neurodevelopmental disorders, Alzheimer´s disease, Stem cells, Organoids
Locus Coeruleus drives novelty-induced dopamine-dependent memory enhancement
Short description
The molecular processes involved in the retention of hippocampus-dependent memories are highly complex. Our research focuses on understanding the character and role of newly synthesized proteins during memory consolidation. We also explore the crucial neural connection between the dorsal hippocampus and the locus coeruleus, specifically investigating the co-release of dopamine and noradrenaline.
Keywords
Memory, Memory consolidation, Hippocampus, Locus coeruleus, Novelty, Protein synthesis, Dopamine, Noradrenaline, Rat